Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2008-09-19
2011-12-13
Sullivan, Daniel (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C514S554000
Reexamination Certificate
active
08076377
ABSTRACT:
Disclosed herein are a novel dicarboxylic acid salt of N,N-dimethylimidodicarbonimidic diamide, a preparation method thereof and a pharmaceutical composition comprising the same. More specifically, disclosed herein are a novel dicarboxylic acid salt of N,N-dimethylimidodicarbonimidic diamide, a crystalline acid addition salt prepared by allowing N,N-dimethylimidodicarbonimidic diamide to react with a specific dicarboxylic acid, which has improved physical and chemical properties including solubility, stability, non-hygroscopicity and anti-adhesive properties, and low toxicity, and thus is very effective in the prevention and treatment of not only diabetes and its complications in patients with so-called metabolic syndromes, in which diabetes, obesity, hyperlipidemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndromes, etc. appear in combination, but also p53 gene-deficient cancers, muscular pain, muscle cytotoxicity and rhabdomyolysis, as well as a preparation method thereof and a pharmaceutical composition comprising the same.
REFERENCES:
patent: 3903141 (1975-09-01), Just et al.
patent: 3957853 (1976-05-01), Bohuon
patent: 4028402 (1977-06-01), Fischer et al.
patent: 4080472 (1978-03-01), Bohuon
patent: 4835184 (1989-05-01), Hugelin et al.
patent: 4879303 (1989-11-01), Davison et al.
patent: 6031004 (2000-02-01), Timmins et al.
patent: 6399658 (2002-06-01), Noguchi et al.
patent: 2003/0220301 (2003-11-01), Lal et al.
patent: 1962661 (2007-05-01), None
patent: WO-99/29314 (1999-06-01), None
patent: WO-99/47128 (1999-09-01), None
patent: WO-02/12177 (2002-02-01), None
patent: WO-2005/033067 (2005-04-01), None
“International Application Serial No. PCT/KR2008/005574, International Search Report mailed Mar. 17, 2009”, 2 pgs.
Buzzai, M., et al., “Systematic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-Deficient Tumor Cell Growth”,Cancer Research, 67(14), (2007), 6745-6752.
Jo Young Gwan
Jun Sung Soo
Kim Byoung Ha
Kim Duck
Kim Sung Wuk
Hanall Pharmaceutical Company, Ltd.
Sawyer Jennifer C
Schwegman Lundberg & Woessner, P.A.
Sullivan Daniel
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