N,N-diaminophthalamides

Details N,N-diaminophthalamides N,N-diaminophthalamides

1986-06-16

1989-09-05

Warren, Charles F.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

564149, 564150, 514166, A61K 31615, A61K 31165, C07C10910

Patent

active

048639672

ABSTRACT:
A compound having the structural formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are hydrogen, C.sub.1 -C.sub.6 alkyl, halogen or C.sub.1 -C.sub.4 alkoxy is disclosed. These compounds demonstrate utility as hypolipidemic agents.
The present invention is also directed to a process for controlling lipidemia in mammals comprising treating mammals with a lipidemia controlling effective amount of the above-defined compound.
Yet another aspect of the present invention is embodied in a pharmaceutical composition comprising the above compound and a pharmaceutically acceptable carrier therefor.

REFERENCES:
patent: 2615862 (1952-10-01), McFarlane et al.
patent: 3222372 (1965-12-01), Weidinger et al.
patent: 3502685 (1970-03-01), Gevirtz et al.
patent: 3631005 (1971-12-01), Fan
patent: 4158014 (1979-06-01), Musser
patent: 4310545 (1982-01-01), Shepherd
patent: 4311846 (1982-01-01), Shepherd
Chemical Abstracts 105:9100(h) Dec. 1986.
Chemical Abstracts 65.7865b (1966).
Chemical Abstracts 54:759g (1960).
Murphy et al. Pharmaceutical Research, vol. 3, No. 2, pp. 93-101 (1986).
Bee et al. Yao Hsiiek Hsueh Pao, 7, 109-118 (1959).
Fournier et al. Therapie, 21 (3), 787-796 (1966).
Offe et al., Z. Naturforsch, vol. 7B, 449-455, 1952.

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