Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-06-22
1994-09-20
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142322, 5142358, 514252, 514255, 540589, 544 60, 544121, 544357, 544366, 544379, 544383, 544388, 544389, 544390, 548254, 5483341, 548540, 562844, A61K 31495, A61K 3154, C07D40312, C07D40914
Patent
active
053489551
ABSTRACT:
Diacylpiperazines of general structural formula: ##STR1## are: angiotensin II (A-II) antagonists with affinity for both AT.sub.1 and AT.sub.2 receptors useful in the treatment of hypertension, congestive heat failure, cerebrovascular, cognitive, and CNS disorders.
REFERENCES:
patent: 3288795 (1966-11-01), Irikura et al.
patent: 4089958 (1978-05-01), Freed et al.
patent: 4138564 (1979-02-01), Freed et al.
patent: 4758652 (1988-07-01), Hertz et al.
patent: 4923870 (1990-05-01), Braquest et al.
patent: 4943578 (1990-07-01), Naylor et al.
patent: 5064838 (1991-11-01), Carr et al.
Rivett et al Australian J. Chem., 19, 165 (1966).
Korzycka et al., Pol. J. Pharmacol. Pharm., 38, 545 (1986).
Toldy et al., Acta. Chim. Acad. Sci. Hung., 70, 101 (1971).
Bigge et al., Tetrahedron Lett., 30, 5193 (1989).
Soai, et al., Bull. Chem. Soc. Japan, 60 (9), 3450-3452 (1987).
Birch, et al., Bioorg. & Med. Chem. Lett., 2 (10), 1275-1278 (1992).
Emonds-Alt, et al., Life Sci., 50, PL-101-PL-106 (1992).
Pat. application Ser. No. 885,416, filed May 19, 1992, by Ashton et al.
Pat. application Ser. No. 905,976, filed Jun. 29, 1992, by Dorn et al.
Pat. application Ser. No. 971,448, filed Nov. 4, 1992, by Dorn et al.
R. S. L. Chang et al., Biochem. and Biophy. Res. Commun, vol. 171, No. 2, pp. 813-817 (Sep. 14, 1990).
S. Whitebread et al., Biochem. and Biophy. Res. Commun, vol. 163, No. 1, pp. 284-291 (Aug. 30, 1989).
Pat. application Ser. No. 935,754, filed Aug. 26, 1992, by Mills et al.
Greenlee William J.
Wu Mu T.
Bernhardt Emily
Camara Valerie J.
Daniel Mark R.
DiPrima Joseph F.
Merck & Co. , Inc.
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