N,N-diacylpiperazine tachykinin antagonists

Details N,N-diacylpiperazine tachykinin antagonists N,N-diacylpiperazine tachykinin antagonists

1992-12-10

1994-09-06

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142278, 5142282, 5142325, 514253, 514255, 514252, 544 60, 544121, 544357, 544360, 544361, 544372, 544387, 544388, 544336, 544390, 558390, 560 25, 560157, A61K 31495, C07D24104, C07D40112, C07D41312

Patent

active

053448308

ABSTRACT:
Diacylpiperazines of general structure ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, and asthma, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.

REFERENCES:
patent: 3288795 (1966-11-01), Irikura et al.
patent: 4804661 (1989-02-01), Ferrini et al.
patent: 4923870 (1990-05-01), Braquest et al.
patent: 4943578 (1990-07-01), Naylor et al.
patent: 5019576 (1991-11-01), Braquest et al.
patent: 5064838 (1991-11-01), Carr et al.
Rivett et al Australian J. Chem., 19, 165 (1966).
Pol. J. Pharmacol. Pharm., 38, 545 (1986), Korzycka et al.
Bull. Chem. Soc. Japan, 60(9), 3450-3452 (1987), Soai, et al.
Tetrahedron Lett., 30, 5193 (1989), Bigge, et al.
Bioorg. & Med. Chem. Lett., 2(10), 1275-1278 (1992), Birch, et al.
Life Sci., 50, PL-101-PL-106 (1992), Emonds-Alt et al.

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