N,N-di(aryl) cyclic urea derivatives as anti-coagulants

Details N,N-di(aryl) cyclic urea derivatives as anti-coagulants N,N-di(aryl) cyclic urea derivatives as anti-coagulants

1995-06-02

1997-03-18

Morris, Patricia L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5483225, 5483231, 5483235, 5483241, 5483245, A61K 31415, C07D23332

Patent

active

056123639

ABSTRACT:
N,N-di(aryl) cyclic urea derivatives, such as the compounds of the following formula: ##STR1## wherein R.sup.1 is --C(NH)NH.sub.2, --C(NH)N(H)OR.sup.11, --C(NH)N(H)C(O)R.sup.9, or --C(NH)N(H)C(O)OR.sup.11 ;

REFERENCES:
patent: 5332822 (1994-06-01), Misra
Tidwell, R. et al., "Strategies for Anticoagulation with Synthetic Protease Inhibitors, Xa Inhibitors Versus Thrombin Inhibitors," Thrombosis Research, (1980) 19:339-349.
Wagner, G. et al., "Synthese von a-a'-Bis[amidinobenzyliden]-und a-a'Bis-[amidinobenzyl]-cycloalkanonen," Pharmazie, (1977) 32, 141-145.
St urzebecher, J. et al., "Cyclic Amides of N.alpha.-arysulfonylaminoacylated 4-amidinophenylalanine--Tight Binding Inhibitors of Thrombin," Thrombosis Research, (1983) 29:635-642.
Kikumoto, R. et al., "Selective inhibition of Thrombin by (2R, 4R)-4-Methyl-1-[N.sup.2 -[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)-sulfonyl]-L-arginyl)]-2piperi dinecarboxylic Acid," Biochemistry, (1984) 23:85-90.
St uzebecher, J. et al., "Synthetic Inhibitors of Serine Proteinases XXIII, Inhibition of Factor Xa by Diamidines", Thrombosis Research, (1980) 17:545:548.

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