N,N-di(aryl) cyclic urea derivatives as anti-coagulants

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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5142345, 514252, 514253, 514317, 514322, A61K 31535, A61K 31495, A61K 3150, A61K 31445

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active

058639144

ABSTRACT:
N,N-di(aryl) cyclic urea derivatives, such as the compounds of the following formula: ##STR1## wherein R.sup.1 is --C(NH)NH.sub.2, --C(NH)N(H)OR.sup.11, --C(NH)N(H)C(O)R.sup.9, or --C(NH)N(H)C(O)OR.sup.11 ;

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Tidwell, R. et al., "Strategies for Anticoagulation with Synthetic Protease Inhibitors, Xa Inhibitors Versus Thrombin Inhibitors," Thrombosis Research, (1980) 19:339-349.
Sturzebecher, J. et al., "Cyclic Amides of N.alpha.-arysulfonylaminoacylated 4-amidinophenylalanine --Tight Binding Inhibitors of Thrombin," Thrombosis Research, (1983) 29:635-642.
Kikumoto, R. et al., "Selective inhibition of Thrombin by dinecarboxylic Acid," Biochemistry, (1984) 23:85-90.
Sturzebecher, J. et al., "Synthetic Inhibitors of Serine Proteinases XXIII, Inhibition of Factor Xa by Diamidines", Thrombosis Research, (1980) 17:545-548.

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