N,N-di(aryl) cyclic urea derivatives as anti-coagulants

Details N,N-di(aryl) cyclic urea derivatives as anti-coagulants N,N-di(aryl) cyclic urea derivatives as anti-coagulants

1996-12-12

1998-03-17

Morris, Patricia L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514252, 514341, 544124, 544364, 5462741, A61K 31535, A61K 31415, C07D41310, C07D40310

Patent

active

057286973

ABSTRACT:
N,N-di(aryl) cyclic urea derivatives, such as the compounds of the following formula: ##STR1## wherein R.sup.1 is --C(NH)NH.sub.2, --C(NH)N(H)OR.sup.11, --C(NH)N(H)C(O)R.sup.9, or --C(NH)N(H)C(O)OR.sup.11 ;

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Kikumoto, R. et al., "Selective inhibition of Thrombin by inecarboxylic Acid," Biochemistry, (1984) 23:85-90.
Sturzebecher, J. et al., "Synthetic Inhibitors of Serine Proteinases XXIII, Inhibition of Factor Xa by Diamidines", Thrombosis Research, (1980) 17:545-548.
Wagner, G. et al., "Synthese von N-Amidinobenzylverbindungen von Salicylamid, 2-4-Dioxodihydro-5.6-benzoxazin-(1.3) und -benzothiazin-(1.3) sowie von 2.4-Dioxo-1.2.3.4-tetrahydrochinazolin", Die Pharmazie, (1978) 33:15-19.

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