N,N'-cycloalkyl/alkyl carboxamide 4H-imidazo-[4,5-b]pyridine com

Details N,N'-cycloalkyl/alkyl carboxamide 4H-imidazo-[4,5-b]pyridine com N,N'-cycloalkyl/alkyl carboxamide 4H-imidazo-[4,5-b]pyridine com

1993-01-22

1993-11-16

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 63, 5142342, 514255, 544127, 544362, 544405, 546 14, 546118, A61K 31435, C07D47104

Patent

active

052624269

ABSTRACT:
A class of N,N'-cycloalkyl/alkyl benzamides of certain 4H-imidazo[4,5-b]pyridine compounds is described for treating cardiovascular and immuno-inflammatory related disorders mediated by platelet activating factor (PAF). Compounds of particular interest are those of the formula: ##STR1## wherein R.sup.1 is selected from hydrido, alkyl, hydroxyalkyl, alkoxyalkyl, phenyl, halophenyl, pyridinyl, alkylsilyloxyalkyl, amino, monoalkylamino, dialkylamino, aminoalkyl, monoalkylaminoalkyl and dialkylaminoalkyl; wherein each of R.sup.5, R.sup.6, R.sup.7 and R.sup.8 is independently selected from hydrido, hydroxy, alkyl, alkoxy, fluoro, chloro, bromo, haloalkyl, alkylthio, alkoxyalkyl, hydroxyalkyl, alkylthioalkyl, cyano, amino, monoalkylamino and dialkylamino; wherein each of R.sup.9 and R.sup.10 is independently selected from hydrido, alkyl, cycloalkyl, bicycloalkyl, heterocyclic, heterocyclicalkyl, aryl, alkenyl and cycloalkenyl, and wherein any of said R.sup.9 and R.sup.10 substituents may be further substituted with one or more groups selected from linear or branched lower alkyl, lower alkoxy, fluoro, chloro and bromo; or a pharmaceutically-acceptable salt thereof.

REFERENCES:
patent: 2987518 (1961-06-01), Hoffman et al.
patent: 4003908 (1977-01-01), Denzel et al.
patent: 4243671 (1981-01-01), Harris et al.
patent: 4284641 (1981-08-01), Thorogood
patent: 4357340 (1982-11-01), Thorogood
patent: 4416895 (1983-11-01), Thorogood
patent: 4579862 (1986-04-01), Manley et al.
patent: 4804658 (1989-02-01), Manley et al.
patent: 4914108 (1990-04-01), Khanna et al.

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