N,N'-bis(sulfonamido)-2-amino-4-iminonaphthalen-1-ones and N,N'-

Details N,N'-bis(sulfonamido)-2-amino-4-iminonaphthalen-1-ones and N,N'- N,N'-bis(sulfonamido)-2-amino-4-iminonaphthalen-1-ones and N,N'-

1992-10-23

1994-03-08

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514252, 514256, 514259, 514260, 514269, 514272, 514275, 514332, 514338, 514339, 514340, 514341, 514342, 514343, 514361, 514378, 514380, 514603, 514616, 544224, 544238, 544239, 544240, 544241, 544295, 544298, 544322, 544333, 544334, 544335, 544283, 544284, 546255, 546271, 546272, 546276, 546278, 546283, 546284, 548243, 548244, 548245, 548246, 548247, 548128, 548129, 564 86, 564155, A61K 3150, A61K 31505, A61K 3144, C07D23708, C07D40112, C07D26108, C07D23924

Patent

active

052927377

ABSTRACT:
N,N'-Bis(sulfonamido)-2-amino-4-iminonaphthalen-1-ones and N,N'-Bis(amido)-2-amino-4-iminonaphthalen-1-ones are disclosed. Methods of inhibiting protein kinase C activity which comprises contacting protein kinase C with an effective amount of an N,N'-Bis(sulfonamido)-2-amino-4-iminonaphthalen-1-one or an N,N'-Bis(amido)-2-amino-4-iminonaphthalen-1-one are disclosed. Methods of treating an animal that is suspected of suffering from inflammatory, cardiovascular and/or neoplastic diseases which comprises administering an effective amount of an N,N'-Bis(sulfonamido)-2-amino-4-iminonaphthalen-1-one or an N,N'-Bis(amido)-2-amino-4-iminonaphthalen-1-one are disclosed.

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