N,N'-Bis[substituted-1,2,3,4 tetrahydroisoquinolyl]disulfonylimi

Details N,N'-Bis[substituted-1,2,3,4 tetrahydroisoquinolyl]disulfonylimi N,N'-Bis[substituted-1,2,3,4 tetrahydroisoquinolyl]disulfonylimi

1980-05-27

1982-03-02

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546139, 546140, 546143, C07D21716, A61K 3147

Patent

active

043178260

ABSTRACT:
Imidodisulfamide derivatives useful in the treatment of allergic conditions are prepared by reaction of an appropriately substituted tetrahydroisoquinoline and bis (chlorosulfonyl)imide in the presence of a tertiary amine. Pharmaceutical compositions and methods of inhibiting the symptoms of an allergic response are also disclosed.

REFERENCES:
patent: 3882148 (1975-05-01), Augstein et al.
patent: 4179507 (1979-12-01), Stenlake et al.
patent: 4252818 (1981-02-01), Rokach et al.
"Chem. Eng. News," May 11, 1970, pp. 103-104.
Appleton, et al., "J. Med. Chem." vol. 20, 1970, pp. 371-379.
Chand, "Agents and Action," vol. 912, 1979, pp. 133-140.
Appel, et al., "Angew. Chem.," Internat. Ed., vol. 6, 1967, p. 652.
Birchall, et al., "J. Amer. Chem. Soc." Dalton. Trans., 1977, pp. 1976-1980.

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