N,N'-bis[3-substituted-4-hydroxypheyl)-2-hydroxyethyl)] -polymet

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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2603437, 260453AR, 260471A, 2605011, 26050112, 26050118, 26050119, 2605012, 260553A, 260556A, 260556N, 260559R, 260559D, 260562R, 2605705C, 2605705P, 2605708R, 260575, 260592, 424280, 424316, 424320, 424321, 424322, 424330, C07C 9122

Patent

active

039339130

ABSTRACT:
N,N'-Bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or-2-hydroxyethyl]-polymethylenediamines having .beta.-adrenergic stimulant activity particularly as selective bronchodilators, are prepared generally by condensation of an N-benzylphenethylamine with a polymethylene dihalide or by reaction of an .alpha.-bromoacetophenone with an N,N'-dibenzyl-polymethylenediamine, with further operations depending on the nature of the 3-substituent, and subsequently hydrogenating catalytically with for example palladium-on-carbon. The key intermediates are also part of the invention.

REFERENCES:
patent: 3329709 (1967-07-01), Schmid et al.

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