Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1972-09-08
1976-01-20
Hines, R. V.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
2603437, 260453AR, 260471A, 2605011, 26050112, 26050118, 26050119, 2605012, 260553A, 260556A, 260556N, 260559R, 260559D, 260562R, 2605705C, 2605705P, 2605708R, 260575, 260592, 424280, 424316, 424320, 424321, 424322, 424330, C07C 9122
Patent
active
039339130
ABSTRACT:
N,N'-Bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or-2-hydroxyethyl]-polymethylenediamines having .beta.-adrenergic stimulant activity particularly as selective bronchodilators, are prepared generally by condensation of an N-benzylphenethylamine with a polymethylene dihalide or by reaction of an .alpha.-bromoacetophenone with an N,N'-dibenzyl-polymethylenediamine, with further operations depending on the nature of the 3-substituent, and subsequently hydrogenating catalytically with for example palladium-on-carbon. The key intermediates are also part of the invention.
REFERENCES:
patent: 3329709 (1967-07-01), Schmid et al.
Colella Donald F.
Kaiser Carl
Edgerton William H.
Foggio Richard D.
Hines R. V.
SmithKline Corporation
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