Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1975-10-16
1977-05-17
Wyman, Daniel E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
260471C, 260553R, 260562P, 260562A, 26057055, 2605706, 424300, 424311, 424330, A61K 31165, A61K 31135, C07C10364, C07C 9112
Patent
active
040242811
ABSTRACT:
N,N'-Bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or -2-hydroxyethyl]-polymethylenediamines having .beta.-adrenergic stimulant activity particularly as selective bronchodilators, are prepared generally by condensation of an N-benzylphenethylamine with a polymethylene dihalide or by reaction of an .beta.-bromoacetophenone with an N,N'-dibenzyl-polymethylenediamine, with further operations depending on the nature of the 3-substituent, and subsequently hydrogenating catalytically with for example palladium-on-carbon. The key intermediates are also part of the invention.
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Colella Donald F.
Kaiser Carl
Edgerton William H.
Foggio Richard D.
SmithKline Corporation
Waltz Thomas A.
Wyman Daniel E.
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