N-methylphenylserine alkyl ester derivatives and uses thereof

Details N-methylphenylserine alkyl ester derivatives and uses thereof N-methylphenylserine alkyl ester derivatives and uses thereof

1993-05-04

1994-02-22

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562446, C07C22936, A61K 3124

Patent

active

052888983

ABSTRACT:
As new compounds are now provided N-methyl-3-(3,4-dihydroxyphenyl)serine alkyl esters which are effective as an .alpha.-adrenergic and .beta.-adrenergic agent to stimulate the .alpha.-adrenergic and .beta.-adrenergic functions of the central nervous system of mammalian animals and are expectable to be useful for therapeutic treatment of disorders as invoked by reduced biological activities or functions of the .alpha.- and/or .beta.-adrenergic neurons. N-methyl-L-threo-3-(3,4-dihydroxyphenyl)serine (C.sub.1 -C.sub.6) alkyl esters are preferred amongst the new compounds of this invention.

REFERENCES:
Microbiological Research Foundation I, Chemical Abstracts, vol. 101, No. 198196p (1984).
Microbiological Research Foundation II, Chemical Abstracts, vol. 100, No. 175293h (1984).
Chemical Abstracts 94: 4247z (1980).
Castellucci et al., Arzneim.-Forsch, 29(1), pp. 27-31 (1979).
Microbial Research Foundation I, Chemical Abstracts, vol. 101, No. 198196p (1984).
Microbial Research Foundation II, Chemical Abstracts, vol. 100, No. 175293h (1984).

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