Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-04-27
1994-02-15
Tsang, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544339, 544341, A61K 31495, C07D24136
Patent
active
052867277
ABSTRACT:
Diketopiperazine compounds designated N-methylepiamauromine, epiamauromine and cycloechinulin have been isolated from the sclerotia of the fungi Aspergillus ochraceus. The compounds are effective for controlling Coleopteran and Lepidopteran insects. The compounds have the structures: ##STR1## wherein: R is a hydrogen atom or a methyl group, such that the compound formed when R is a hydrogen atom is designated epiamauromine and the compound formed when R is a methyl group is designated N-methylepiamauromine; and cycloechinulin has the structure: ##STR2##
REFERENCES:
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Te Paske et al, J. Org. Chem. 55:5299 (1990).
Gloer et al, J. Org. Chem. 54:2530 (1989).
Takase et al. "Structure of Amauromine, A New Hypotensive Vasodilator Produced By Amaroascus Sp." Tetrahedron, vol. 41, 1985. pp. 3037-3048.
Takase et al. "Structure of Amauromine, A New Alkaloid with Vasolidating Activity Produced By Amauroascus Sp." Tetrahedron Lett., vol. 25, 1984. pp. 4673-4676.
Marchelli et al. "The Structures Of Five New Didehydropeptides Related To Neoechinulin Isolated From Aspergillus amstelodami" J. C. S. Perkin I, 1977. pp. 713-717.
Chang et al. "Chemical Abstracts" vol. 72, 1970, Abstract 67267X.
deGuzman Florecita S.
Dowd Patrick F.
Gloer James B.
Wicklow Donald T.
Biotechnology Research & Development Corporation
The United States of America as represented by the Secretary of
Tsang Cecilia
University of Iowa Research Foundation
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