Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Patent
1996-03-01
1997-09-30
Chan, Nicky
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C07C22520
Patent
active
056727577
ABSTRACT:
N-methyldeacetylcolchiceinamide derivatives represented by the formula ##STR1## wherein R denotes a residue obtained by removing COOH from a C.sub.3 -C.sub.7 sugar carboxylic acid, and hydroxyl groups present in the residue may properly be protected with a protecting group for a hydroxyl group.
The N-methyldeacetylcolchiceinamide derivatives have less toxicity and strong effect for inhibiting proliferation of tumor cells, and are expected to be used as a carcinostatic.
REFERENCES:
patent: 5220002 (1993-06-01), Akiyama
patent: 5326786 (1994-07-01), Akiyama
Martin et al., Cancer Research, 46, 2189-2192 (1986).
Quinn et al., Chemical Abstracts, 94:167, 463f (1981).
van Temelen et al., "The Synthesis Of Colchicine", Tetrahedron, 1961, vol. 14, pp. 8-34, Pergamon Press.
Leiter et al., "Damage Induced In Sarcoma 37 With Chemical Agents. IV. Derivatives of Colchiceinamide.sup.1 ", Journal of the National Cancer-Institute, 13, pp. 731-739 (1952).
Raffauf et al., "Colchicine. Derivatives Of Trimethylcolchicinic Acid.sup.1,2 ", J. Am. Chem. Soc., vol 75,, pp. 5292-5294 (1953).
Davis, "Microbial Transformations Of N-Methylcolchiceinamide", Antimicrobial Agents And Chermotherapy, Mar. 1981, vol. 19, No. 3, pp. 465-469.
Hartwell et al., "N-Substitued Colchicainamides", J. Am. Chem. Soc., vol. 74, pp. 3180-3181 (1952).
Cheal Engng. News, "Demecolcine", vol. 37, No. 41, p. 67 (1957).
Chan Nicky
Ohgen Research Laboratories Ltd.
LandOfFree
N-methyldeacetylcolchiceinamide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with N-methyldeacetylcolchiceinamide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-methyldeacetylcolchiceinamide derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2257924