Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1997-10-09
1999-10-19
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
424 111, 424 165, 424 169, 514430, 514431, 514183, 514247, A61K 5100, A61M 3614
Patent
active
059684780
ABSTRACT:
Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein X.sub.1 is selected from CH.sub.2, NH, O and S;
REFERENCES:
patent: 3539573 (1970-11-01), Schmutz
patent: 3546226 (1970-12-01), Schmutz
patent: 3751415 (1973-08-01), Schmutz
patent: 3758479 (1973-09-01), Schmutz
patent: 3761481 (1973-09-01), Nakanishi et al.
patent: 3811026 (1974-05-01), Kaplan et al.
patent: 3852446 (1974-12-01), Schmutz et al.
patent: 3884920 (1975-05-01), Schmutz et al.
patent: 3908010 (1975-09-01), Schmutz
patent: 3983234 (1976-09-01), Sayers
patent: 4096261 (1978-06-01), Horrom
patent: 4097597 (1978-06-01), Horrom et al.
patent: 4191760 (1980-03-01), Horrom et al.
patent: 4243805 (1981-01-01), Protiva et al.
patent: 5354747 (1994-10-01), Hansen
patent: 5393752 (1995-02-01), Liegeois et al.
patent: 5700445 (1997-12-01), Fu et al.
Jilek et al (1970), Collection Czechoslov. Commun., vol. 35, No. 1, pp. 276-283, "Neurotropic and Psychotropic Compounds.XLI*. 8-cyano-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin and Related Compounds".
Gianai et al, Synthesis, 1985, p. 550, "A new facile synthesis of 11-oxo-10, 11-dihydro-5H-dibenzo[b,e][1,4]diazepines".
Harris et al, J. Med. Chem, 1982, 25:855, "Affinity of 10-(4-methylpiperazino)dibenz[b,f]oxepins for clozapine and spiroperidol binding sites in rat brain".
Klunder et al, J. Med Chem, 1992, 35:1887, "Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase, tricyclic pyridobenzoxazepinones and dibenzoxazepinones".
de Paulis et al, J. Med Chem, 1981, 24(9):1021, "Synthesis of clozapine analogues and their affinity to clozapine and spiroperidol binding sites in rat brain".
Sindelar et al Coll. Czechoslov. Chem. Commun., 1977, 42:2231, Noncataleptic potential neuroleptics: 2-nitro and 2-hydroxy derivatives of 10-(4-methylpiperzino)-10, 11-dihydrodibenzo[b,f]thiepin.
Sindelar et al, 1978. Collection Czechoslov. Chem. Commun. vol. 43, pp. 309-315 "Non Cataleptic Neuroleptics; 8-chloro-2-hydroxy-11-(4-methyl piperazino)-5H-dibenzo[b,e]-1, 4-diazepine as a potential metabolite of clozapine".
Bender et al, 1994, Nucl. Med. Biol., vol. 21, No. 7, pp. 921-925. "Synthesis of n.c.a. Carbon-11 labelled clozapine and its Major Metabolite clozapine-N-oxide and comparison of their Biodistribution in Mice".
Jilek et al, 1975. Collection Czechoslov. Chem. Comm., vol. 40, pp. 2887-2904. Noncataleptic potential neuroleptics; 2-Halogeno-10-piperazino dibenzo [b,f]Thiepins.
Valenta et al, 1978, Collection Czechoslov. Chem. Comm., vol. 41, pp. 3607-3627 Potential Metabolites of Noncataleptic Neuroleptics: 2-chloro-8-hydroxy-10-(4-methyl piperazino)-and-10-[4-(2-hydroxy-ethyl) piperazino]-10, 11-dihydrodibenzo-[b,f]thiepin.
Fouche, J., et al; Bull. Soc. chim.; (8); pp. 3113-3130, Fr., Psychotropic drugs. 11-Piperazino-10, 11-dihydrodibenzo[a,d]cyclohe ptene derivatives (1972).
Schmutz, J., et al.; Chim. Ther.; vol. 2 (6); pp. 424-429; Chemical structure and pharmacological activity of a new group of tricyclic neuroleptics. XI. Heterocycles with seven atoms; 1967.
L. Coscia et al; Arzneim.-Forsch. (ARZNAD); vol. 25, (8) (1975); pp. 1261-1265; New Tricyclic Enamine Derivatives with CNS Depressant Properties (1975).
Chemical Abstracts, vol. 68, No. 23; 1968; 105247.
Chemical Abstracts, vol. 73, No. 11; 1970; 56127.
Chemical Abstracts, vol. 80, No. 11; 1974, 59966.
28-Heterocycles, vol. 80, No. 7, 1974; 37156h.
J.P. Tollenaere et al, Chimica Therapeutica, Jul.-Aug. 1976, vol. 11; No. 4, pp. 293-298; Quantative structure activity relationships (QSAR) in a series of neuroleptic 10-piperazino-dibenzo (b, f) thiepins, ataxia in mice.
Schmutz et al; Helvetica Chimica Acta, vol. 50(1), 1967, pp. 245-249, 29 Heterocycles with 7-membered rings. IX. 11-Amino substituted dibenzo [b,f]-1, 4-thiazepines and--oxazepines.
Fu Jian-Min
Rakhit Sumanas
Allelix Biopharmaceuticals Inc.
Dees Jos,e G.
Jones Dameron
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