Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1994-12-12
1997-12-23
Kight, John
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
424 111, 424 165, 424 169, 514211, A61K 5100, A61M 3614
Patent
active
057004455
ABSTRACT:
Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein X.sub.1 is selected from CH.sub.2, NH, O and S;
REFERENCES:
patent: 3539573 (1970-11-01), Schmutz
patent: 3546226 (1970-12-01), Schmutz
patent: 3751415 (1973-08-01), Schmutz
patent: 3758479 (1973-09-01), Schmutz
patent: 3761481 (1973-09-01), Nakanishi et al.
patent: 3811026 (1974-05-01), Kaplan et al.
patent: 3852446 (1974-12-01), Schmutz et al.
patent: 3884920 (1975-05-01), Schmutz et al.
patent: 3908010 (1975-09-01), Schmutz et al.
patent: 3983234 (1976-09-01), Sayers
patent: 4096261 (1978-06-01), Horrom et al.
patent: 4097597 (1978-06-01), Horrom et al.
patent: 4191760 (1980-03-01), Horrom et al.
patent: 4243805 (1981-01-01), Protiva et al.
patent: 5354747 (1994-10-01), Hansen
patent: 5393752 (1995-02-01), Liegeois et al.
Fouche, J., et al.; Bull. Soc. chim.; (8); pp. 3113-3130, Fr., Psychotropic (1972).
Schmutz, J., et al.; Chim. Ther.; vol. 2 (6); pp. 424-429; Chemical structure and pharmacological activity of a new group of tricyclic neuroleptics. XI. Heterocycles with seven atoms; (1967).
L. Coscia, et al.; Arzneim.-Forsch. (ARZNAD); vol. 25,(8) (1975); pp. 1261-1265; New Tricyclic Enamine Derivatives with CNS Depressant Properties; (1975).
Chemical Abstracts, vol. 68, No. 23; 1968; 105247.
Chemical Abstracts, vol. 73, No. 11; 1970; 56127.
Chemical Abstracts, vol. 80, No. 11; 1974; 59966.
28--Heterocycles, vol. 80, No. 7; 1974; 37156h.
J. P. Tollenaere, et al., Chimica Therapeutica, Jul.-Aug. 1976, vol. 11; No. 4, pp. 293-298; Quantative structure activity relationships (QSAR) in a series of neuroleptic 10-piperazino-dibenzo(b,f)thiepins, ataxia in mice.
Schmutz, et al.; Helvetica Chimica Acta, vol. 50(1), 1967, pp. 245-249, 29, Heterocycles with 7-membered rings. IX. 11-Amino substituted dibenzo
Gianai et al Synthesis, 1985, p.550 "A new facile synthesis of
Harris et al J Med Chem, 1982, 25:855 "Affinity of binding sites in rat brain".
Klunder et al J Med Chem, 1992, 35:1887 "Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. tricyclic pyridobenzoxazepinones and dibenzoxazepinones".
de Paulis et al J Med Chem, 1981, 24(9):1021 "Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain".
Sindelar et al Coll. Czechoslov. Chem. Commun., 1977, 42:2231 "Noncataleptic potential neuroleptics: 2-nitro and 2-hydroxy derivatives
Sindelar et al (1978), Collection Czechoslov. Chem. Commun. vol. 43, pp. 309-315. "Non Cataleptic Neuroleptics; 8-chloro-2-hydroxy-11-4(4-methyl Clozapine".
Bender et al (1994), Nucl. Med. Biol., vol. 21, No. 7, pp. 921-925. "Synthesis of N.C.A. Carbon-11 Labelled Clozapine and Its Major Metabolite Clozapine-N-Oxide and Comparison of Their Biodistribution in Mice".
Jilek et al (1975), Collection Czechoslov. Chem. Commun, vol. 40 pp. 2887-2904. "Noncataleptic Potential Neuroleptics;
Valenta et al (1978). Collection Czechoslov. Chem Commun, vol. 41, pp. 3607-3627. "Potential Metabolites of Noncataleptic Neuroleptics: 2-chloro-8-hydroxy-10-(4-methylpiperazino)-and
Fu Jian-Min
Rakhit Sumanas
Allelix Biopharmaceuticals Inc.
Jones Dameron
Kight John
LandOfFree
N-methyl piperazine compounds having dopamine receptor affinity does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with N-methyl piperazine compounds having dopamine receptor affinity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-methyl piperazine compounds having dopamine receptor affinity will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1800219