N-methyl-N-[(1S)-1-phenyl-2-(3S)-hydroxypyrrolidin-1-yl)ethyl]-2

Details N-methyl-N-[(1S)-1-phenyl-2-(3S)-hydroxypyrrolidin-1-yl)ethyl]-2 N-methyl-N-[(1S)-1-phenyl-2-(3S)-hydroxypyrrolidin-1-yl)ethyl]-2

1996-08-26

2000-05-09

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548453, 548568, A61K 3140, C07D20712

Patent

active

060605049

ABSTRACT:
The invention relates to a novel heat-stable form of N-methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diph enylacetamide and to a process for the preparation and isolation of this compound in this novel form and to use for the production of medicaments which contain this compound and/or one of its physiologically acceptable salts.

REFERENCES:
patent: 5532266 (1996-07-01), Gottschlich et al.
Haleblian, John K., "Characterization of Habits and Crystalline Modification of Solids and Their Pharmaceutical Applications", Journal of Pharmaceutical Sciences, vol. 64, No. 8, pp. 1269-1288 (Aug. 1975).
Haleblian, John K., et al., "Pharmaceutical Applications of Polymorphism", Journal of Pharmaceutical Sciences, vol. 58, No. 8, pp. 911-929 (Aug. 1969).
Gottschlich, R., et al., "EMD 61753 As a Favourable Representative of Structurally Novel Arylacetamido-Type K Oplate Receptor Agonists", Bioorganic & Medicinal Chemistry Letters, vol. 4, No. 5, pp. 677-682 (1944).
Gottschlich, R., et al., "K-Opioid Activity of the Four Stereoisomers of the Peripherally Selective k-Agonists, EMD 60 400 and EMD 61 753", Chirality 6:685-689 (1994).
Pearson, J.T., et al., "The Influence of Crystal Structure on Drug Formulation", Manufacturing Chemist, vol. 44, No. 12 (Jan. 15, 1974).

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