N-Methanesulfonic acid derivatives of istamycin A or B and produ

Details N-Methanesulfonic acid derivatives of istamycin A or B and produ N-Methanesulfonic acid derivatives of istamycin A or B and produ

1981-08-04

1983-09-27

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 161, 536 168, 424181, A61K 3171, C07H 1522

Patent

active

044068913

ABSTRACT:
As new semi-synthetic antibiotic derivative are provided N-methanesulfonic acid derivatives of istamycin A or B which are lower toxic than the parent antibiotic and retain usefully high antibacterial activity. They are produced by N-sulfomethylation in such way that istamycin A or B is reacted with an aldehyde such as paraformaldehyde and sulfurous acid or sulfite reagent.

REFERENCES:
patent: 4091202 (1978-05-01), Umezawa et al.
patent: 4250304 (1981-02-01), Martin et al.
patent: 4273924 (1981-06-01), Martin et al.
patent: 4276413 (1981-06-01), Martin et al.
patent: 4283529 (1981-08-01), Rosenbrook, Jr.
patent: 4296106 (1981-10-01), Umezawa et al.

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