N-Methanesulfonic acid derivatives of 3-O-demethylistamycin B an

Details N-Methanesulfonic acid derivatives of 3-O-demethylistamycin B an N-Methanesulfonic acid derivatives of 3-O-demethylistamycin B an

1983-01-18

1984-09-18

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 161, 536 168, A61K 3170, C07H 1522

Patent

active

044723881

ABSTRACT:
New semi-synthetic antibiotic derivative are formed from N-methanesulfonic acid derivatives of 3-O-demethylistamycin B which are less toxic than the parent 3-O-demethylistamycin B and retain usefully high antibacterial activity of the parent antibiotic. The new derivatives are produced by a method of N-sulfomethylation where 3-O-demethylistamycin B is reacted with an aldehyde such as paraformaldehyde and sulfurous acid or sulfite reagent.

REFERENCES:
patent: 4091202 (1978-05-01), Umezawa et al.
patent: 4296106 (1981-10-01), Umezawa et al.
patent: 4382926 (1983-05-01), Umezawa et al.

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