N-Methanesulfonic acid derivatives of 3-demethoxyistamycin B

Details N-Methanesulfonic acid derivatives of 3-demethoxyistamycin B N-Methanesulfonic acid derivatives of 3-demethoxyistamycin B

1984-05-08

1986-01-28

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 137, 536 161, 536 168, A61K 3171, C07H 1522

Patent

active

045671656

ABSTRACT:
As new semi-synthetic antibiotic derivatives are provided N-methanesulfonic acid derivatives of 3-demethoxyistamycin B which are less toxic than the parent 3-demethoxyistamycin B but retain usefully high antibacterial activity of the parent antibiotic. The new derivatives are produced by a method of N-sulfomethylation where 3-demethoxyistamycin B is reacted with an aldehyde such as paraformaldehyde and sulfurous acid or sulfite reagent.

REFERENCES:
patent: 4091202 (1978-05-01), Umezawa et al.
patent: 4296106 (1981-10-01), Umezawa et al.
patent: 4382926 (1983-05-01), Umezawa et al.
patent: 4472388 (1984-09-01), Umezawa et al.
patent: 4479943 (1984-10-01), Umezawa et al.

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