N-methanesulfonic acid derivatives of 3',4'-dideoxykanamycin B

Details N-methanesulfonic acid derivatives of 3',4'-dideoxykanamycin B N-methanesulfonic acid derivatives of 3',4'-dideoxykanamycin B

1976-09-16

1978-05-23

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, C07H 1522, A61K 3171

Patent

active

040912027

ABSTRACT:
As new semi-synthetic antibiotic derivative are provided N-methanesulfonic acid derivatives of 3',4'-dideoxykanamycin B which are less toxic than the parent antibiotic and have useful high antibacterial activity. They are produced by interacting 3',4'-dideoxykanamycin B, an aldehyde such as paraformaldehyde and sulfurous acid or an alkali metal sulfite reagent.

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patent: 4001208 (1977-01-01), Umezawa et al.

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