N-maleimidyl polymer derivatives

Details N-maleimidyl polymer derivatives N-maleimidyl polymer derivatives

2005-06-28

2005-06-28

Spear, James M. (Department: 1615)

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

C424S078310, C424S078320, C424S078330

Reexamination Certificate

active

06911197

ABSTRACT:
The invention is directed to multi-functional N-maleimidyl polymer derivatives comprising a water soluble and non-peptidic polymer backbone having a terminal carbon, such as a poly(alkylene glycol), the terminal carbon of the polymer backbone being directly bonded to the nitrogen atom of a N-maleimidyl moiety without a linking group therebetween. The invention also provides two methods of preparing such linkerless N-maleimidyl polymer derivatives.

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