Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-06-26
2010-06-01
Andres, Janet L (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S318000, C514S319000, C514S320000, C514S321000, C514S322000, C514S323000, C514S328000, C514S329000, C514S330000, C514S331000, C546S184000, C546S193000, C546S194000, C546S242000, C546S244000, C546S246000, C546S248000
Reexamination Certificate
active
07728008
ABSTRACT:
The present invention provides novel ureas containing N-aryl or N-heteroaryl substituted heterocycles of Formula (I):or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, D and W are as defined herein. These compounds are selective inhibitors of the human P2Y1receptor which can be used as medicaments.
REFERENCES:
patent: 3118888 (1964-01-01), Giraldi et al.
patent: 3162644 (1964-12-01), Englisch et al.
patent: 4179563 (1979-12-01), Butler
patent: 4186199 (1980-01-01), Glamkowski et al.
patent: 4435391 (1984-03-01), Sasahara et al.
patent: 4663453 (1987-05-01), Glamkowski et al.
patent: 4840947 (1989-06-01), Glamkowski et al.
patent: 4886822 (1989-12-01), Shibuya et al.
patent: 5500424 (1996-03-01), Nagamine et al.
patent: 5547966 (1996-08-01), Atwal et al.
patent: 5612359 (1997-03-01), Murugesan
patent: 5708008 (1998-01-01), Audia et al.
patent: 5886004 (1999-03-01), Audia et al.
patent: 6020357 (2000-02-01), Pinto et al.
patent: 6043265 (2000-03-01), Murugesan et al.
patent: 6143764 (2000-11-01), Kubo et al.
patent: 6180675 (2001-01-01), Widdowson et al.
patent: 6187797 (2001-02-01), Pruitt et al.
patent: 6329395 (2001-12-01), Dugar et al.
patent: 6586453 (2003-07-01), Dhanoa et al.
patent: 6596746 (2003-07-01), Das et al.
patent: 6656933 (2003-12-01), Hickey
patent: 6825355 (2004-11-01), Das et al.
patent: 6863647 (2005-03-01), Pevarello et al.
patent: 2002/0077486 (2002-06-01), Scarborough et al.
patent: 2003/0061667 (2003-04-01), Lim et al.
patent: 2003/0065176 (2003-04-01), Kang et al.
patent: 2003/0153568 (2003-08-01), Cusack et al.
patent: 2003/0195232 (2003-10-01), Kawasaki et al.
patent: 2003/0207870 (2003-11-01), Dumas et al.
patent: 2003/0216396 (2003-11-01), Dumas et al.
patent: 2004/0023961 (2004-02-01), Dumas et al.
patent: 2004/0038992 (2004-02-01), Bemis et al.
patent: 2004/0102636 (2004-05-01), Miller et al.
patent: 2004/0209930 (2004-10-01), Carboni et al.
patent: 2004/0259875 (2004-12-01), Yura et al.
patent: 2005/0009815 (2005-01-01), DeVita et al.
patent: 2005/0012254 (2005-01-01), Hsu
patent: 2005/0119304 (2005-06-01), Yura et al.
patent: 2005/0203146 (2005-09-01), Herpin et al.
patent: 2005/0256161 (2005-11-01), Tempest et al.
patent: 2005/0261244 (2005-11-01), Tuerdi et al.
patent: 2005/0267119 (2005-12-01), Chao et al.
patent: 2006/0173002 (2006-08-01), Sutton et al.
patent: 2006/0293336 (2006-12-01), Sutton et al.
patent: 2006/0293522 (2006-12-01), Sutton
patent: 2007/0004677 (2007-01-01), Chao et al.
patent: 0 028 489 (1981-05-01), None
patent: 129692 (1985-01-01), None
patent: 0265734 (1988-05-01), None
patent: 0 286 979 (1988-10-01), None
patent: 0 638 557 (1995-02-01), None
patent: 1 120 409 (2001-08-01), None
patent: 1 123 918 (2001-08-01), None
patent: 1 402 888 (2004-03-01), None
patent: 1 661 879 (2006-05-01), None
patent: 1712242 (2006-10-01), None
patent: 1 342 550 (1962-12-01), None
patent: 56-167649 (1981-12-01), None
patent: 62-280847 (1987-12-01), None
patent: 3-39740 (1991-02-01), None
patent: 04319958 (1991-04-01), None
patent: 7-101153 (1995-04-01), None
patent: 2001-89412 (2001-04-01), None
patent: WO 96/17825 (1996-06-01), None
patent: WO 97/29743 (1997-08-01), None
patent: WO98/18430 (1998-05-01), None
patent: WO 98/37035 (1998-08-01), None
patent: WO 98/57951 (1998-12-01), None
patent: WO 99/31086 (1999-06-01), None
patent: WO 99/32463 (1999-07-01), None
patent: WO 00/01389 (2000-01-01), None
patent: WO 00/59506 (2000-10-01), None
patent: WO 00/76495 (2000-12-01), None
patent: WO 00/76970 (2000-12-01), None
patent: WO 01/23358 (2001-04-01), None
patent: WO 01/40231 (2001-06-01), None
patent: WO 01/47919 (2001-07-01), None
patent: WO 01/51490 (2001-07-01), None
patent: WO 01/55146 (2001-08-01), None
patent: WO 01/57008 (2001-08-01), None
patent: WO 01/72751 (2001-10-01), None
patent: WO 02/44145 (2002-06-01), None
patent: WO 02/064211 (2002-08-01), None
patent: WO 02/088090 (2002-11-01), None
patent: WO 02/090352 (2002-11-01), None
patent: WO 03/007955 (2003-01-01), None
patent: WO 03/013517 (2003-02-01), None
patent: WO 03/014064 (2003-02-01), None
patent: WO 03/026652 (2003-04-01), None
patent: WO 03/045920 (2003-06-01), None
patent: WO 03/055484 (2003-07-01), None
patent: WO 03/055848 (2003-07-01), None
patent: WO 03/080553 (2003-10-01), None
patent: WO 2004/002481 (2004-01-01), None
patent: WO 2004/012733 (2004-02-01), None
patent: WO 2004/022529 (2004-03-01), None
patent: WO 2004/046090 (2004-06-01), None
patent: WO 2004/060907 (2004-07-01), None
patent: WO 2004/085433 (2004-10-01), None
patent: WO 2004/110374 (2004-12-01), None
patent: WO 2005/037763 (2005-04-01), None
patent: WO 2005/042488 (2005-05-01), None
patent: WO2005063293 (2005-07-01), None
patent: WO 2005/070920 (2005-08-01), None
patent: WO2006/091963 (2006-08-01), None
U.S. Appl. No. 11/872,816, filed Oct. 16, 2007, Lam et al.
Atwal, K.S. et al., “Cardioselective Antiischemic ATP-Sensitive Potassium Channel Openers. 4. Structure-Activity Studies on Benzopyranylcyanoguanidines: Replacement of the Benzopyran Portion”, Journal of Medicinal Chemistry, vol. 39, No. 1, pp. 304-313 (1996).
Bareich, D.C. et al., “Simultaneous in Vitro Assay of the First Four Enzymes in the Fungal Aspartate Pathway Identifies a New Class of Aspartate Kinase Inhibitor”, Chemistry & Biology, vol. 10, pp. 967-973 (2003).
Beaver, D.J. et al., “The Preparation and Bacteriostatic Activity of Substituted Ureas”, J. Am. Chem. Soc., vol. 79, pp. 1236-1245 (1957).
Bensemann, I. et al., “Creation of hydrogen bonded 1D networks by co-crystallization ofN,N′-bis(2-pyridyl)aryldiamines with dicarboxylic acids”, Org. Biomol. Chem., vol. 1, pp. 1425-1434 (2003).
Bundgaard, H., Chapter 5: “Design and Application of Prodrugs”, A Textbook of Drug Design and Development, Harwood Academic Publishers, publ., Krogsgaard-Larsen, P. et al., eds., pp. 113-191 (1991).
Bundgaard, H., “Prodrugs as a means to improve the delivery of peptide drugs”, Advanced Drug Delivery Reviews, vol. 8, pp. 1-38 (1992).
Chan, D.M.T. et al., Chapter 5: “Recent Advances in Copper-promoted C-Heteroatom Bond Cross-coupling Reactions with Boronic Acids and Derivatives”, Boronic Acids: Preparation and Applications in Organic Synthesis and Medicine, Wiley-VCH Verlag GmbH & Co., publ., Hall, D.G., ed., pp. 205-240 (2005).
Chou, T.-C. et al., “Quantitative Analysis of Dose-Effect Relationships: The Combined Effects of Multiple Drugs or Enzyme Inhibitors”, Adv. Enzyme Regul., vol. 22, pp. 27-55 (1984).
Cobern, D. et al., “Some Newp-Chlorophenoxycarbanilides and Their Bacteriostatic Activities”, J. Med. Chem., vol. 11, pp. 163-164 (1968).
Duncan, Jr., R.L. et al., “Synthesis of Indolo- and Benzimidazoquinazolines and Benzodiazepines”, Journal of Heterocyclic Chemistry, vol. 10, pp. 65-70 (1973).
Gallou, I. et al., “Practical Synthesis of Unsymmetrical Ureas from Isopropenyl Carbamates”, J. Org. Chem., vol. 70, No. 17, pp. 6960-6963 (2005).
Gramatica, P. et al., “QSAR approach for the selection of congeneric compounds with a similar toxicological mode of action”, Chemosphere, vol. 42, pp. 873-883 (2001).
Gschwend, D.A. et al., “Specificity in Structure-Based Drug Design: Identification of a Novel, Selective Inhibitor ofPneumocystis cariniiDihydrofolate Reductase”, Proteins: Structure, Function and Genetics, vol. 29, pp. 59-67 (1997).
Hai, P.V. et al., “p-Cyclopentylacetophenone and Its Derivatives”, J. Org. Chem., vol. 23, pp. 39-42 (1958).
Hamada, Y. et al., “The antimicrobial activity and syntheses of carbanilide derivatives,” Yakugaku Zasshi, vol. 96, No. 5, pp. 663-668 (1976) (English abstract).
Ito, Y. et al., “Syntheses of Nitrogen-containing Heterocyclic Compounds. XXIX. An Improved Method for the Preparation of 10H-Pyrido[3,2-b][1,4]benzoxazine (1-Azaphenoxazine)”, Chem. Pharm. Bull., vol. 26, No. 5, pp. 1375-1383 (1978).
Jin, J. et al.,
Gungor Timur
Qiao Jennifer
Sutton James C.
Wang Tammy C.
Andres Janet L
Bristol--Myers Squibb Company
Gallis David E
Sun Jing G.
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