N-(indole-2-carbonyl) and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S428000, C514S430000, C514S432000, C514S446000, C548S452000, C548S453000, C549S013000, C549S070000, C549S083000, C549S088000

Reexamination Certificate

active

06992101

ABSTRACT:
The present invention provides compounds of formula (I)the prodrugs thereof, and the pharmaceutically acceptable salts of the compounds and prodrugs, wherein R′, R″, R′″, and Z are as defined herein; pharmaceutical compositions thereof; and uses thereof in treating diabetes, insulin resistance, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, cataracts, hyperglycemia, hypercholesterolemia, hypertension, hyperinsulinemia, hyperlipidemia, atherosclerosis, and tissue ischemia.

REFERENCES:
patent: 6576653 (2003-06-01), Du Bois
patent: 1340500 (2003-09-01), None
patent: 1088824 (2004-01-01), None
patent: WO 9639384 (1996-12-01), None
patent: WO 9639385 (1996-12-01), None
patent: WO 0220530 (2002-03-01), None
patent: WO 03074484 (2003-09-01), None

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