"N-imidazolyl derivatives of bicyclic compounds and pharmaceutic

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...


Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0


514397, 514399, 514866, A61K 31415




A pharmaceutical compositon having activity against nephropathies comprising, as an active agent, a therapeutically effective amount of a compound of formula (I) ##STR1## wherein (a) ##STR2## wherein Y completes a single bond or is oxygen or a --CH.sub.2 -- group and the symbol ##STR3## represents a single bond or (b) ##STR4## ##STR5## and the symbol ##STR6## represents a double bond; one of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is --CH.sub.2 OH, C.sub.2 -C.sub.4 acyl, ##STR7## in which each of R.sub.1, R.sub.8 and R.sub.9 is independently hydrogen or C.sub.1 -C.sub.4 alkyl and the others are independently chosen from hydrogen, hydroxy, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy and --COOR, wherein R.sub.7 is as defined above, and one of R.sub.5 and R.sub.6 is hydrogen and the other is hydrogen, C.sub.1 -C.sub.6 alkyl or phenyl; or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier and/or diluent.

patent: 3992403 (1976-11-01), Roebke
patent: 4492707 (1985-01-01), Cozzi et al.
patent: 4510149 (1985-03-01), Cozzi et al.
patent: 4588738 (1986-05-01), Cozzi et al.
patent: 4602022 (1986-07-01), Cozzi et al.
patent: 4634705 (1987-01-01), De Bernardis et al.
Cecil, "Textbook of Medicine", Sixteenth Edition, Saunders, (1982).
Whitley et al., "Acute Glomerulonephritis" Medical Clinics of North America-vol. 68, No. 2, Mar. 1984.
Am. J. Med. 64, 804-807 (1978)-Kimberly et al.
Kidney Intern. 30 (1986) 760-768-Toto et al.
Nephron 45 306-310 (1987)-Izumino et al.
Kidney Intern. 27, 189A (1985), Dworkin et al.
Hypertension & Glomerular Injury in Rats-J. Clin. Invest. 77 (1986), 1993-2000-Anderson, now Eng. J. Med. 296(8)-418-424 (1977) Kimberly et al.


Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.


"N-imidazolyl derivatives of bicyclic compounds and pharmaceutic does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with "N-imidazolyl derivatives of bicyclic compounds and pharmaceutic, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and "N-imidazolyl derivatives of bicyclic compounds and pharmaceutic will most certainly appreciate the feedback.

Rate now


Profile ID: LFUS-PAI-O-1426328

All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.