N-hydroxysuccinimide process for conversion of phenols to...

Details N-hydroxysuccinimide process for conversion of phenols to... N-hydroxysuccinimide process for conversion of phenols to...

2006-06-06

2006-06-06

Saeed, Kamal A. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C546S074000, C548S542000

Reexamination Certificate

active

07057035

ABSTRACT:
A process for converting an aryl triflate, heteroaryl triflate, aryl halide or heteroaryl halide to an N-hydroxysuccinimido ester is disclosed. The process involves reacting the triflate or halide with carbon monoxide and N-hydroxysuccinimide in a solvent in the presence of a palladium catalyst and a base.

REFERENCES:
patent: 5734064 (1998-03-01), Pochlauer et al.
patent: 6376230 (2002-04-01), Aikins et al.
Lou et al., “Preparation of N-hydroxysuccinimido esters via palladium-catalyzed carbonylation of aryl triflates and halides,” Tetrahedron Letters, Elsevier Science Publishers, 44(12) pp. 2477-2480 (2003).
Wentland et al., “8-Carboxamidocyclazocine Analogues: Redefining the Structure-Activity Relationships of 2,6-Methano-3-benzazocines,” Bioorganic & Medicinal Chemistry Letters, 11(5) pp. 623-626 (2001).

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