N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxyth

Details N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxyth N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxyth

1989-05-26

1991-01-01

Gray, Bruce

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

N-c doai

514482, 514510, 514522, 514539, 514562, 514563, 514575, 514645, 558412, 558413, 558414, 558417, 558419, 558422, 560 9, 560 13, 560 19, 560 21, 560 27, 560 28, 560 34, 560 39, 560 41, 562426, 562430, 562435, 562439, 562448, 562449, 562450, 562621, 562622, 562623, 564300, A61K 3127

Patent

active

049818651

ABSTRACT:
The present invention includes N-hydroxyamide, N-hydroxyurea, N-hydroxythioamide, and N-hydroxythiourea derivatives of fenamates, indomethacin, cicloprofen, oxepinac, and indoprofen as dual inhibitors or selective inhibitors of cyclooxygenase and 5-lipoxygenase.

REFERENCES:
patent: 4092430 (1978-05-01), Sallmann et al.
patent: 4173577 (1979-11-01), Sallmann et al.
patent: 4604407 (1986-08-01), Haslanger et al.
patent: 4705782 (1987-11-01), Logan et al.
patent: 4769387 (1988-09-01), Summers et al.
Jackson et al., J. Med. Chem., vol. 31, No. 3, pp. 500-503, (1988).
J. Org. Chem., vol. 54, No. 5, 1989, 1221-1223, A. O. Stewart et al.
J. Medicinal Chem., 1988, vol. 31, 3-5, J. B. Summers et al.
J. Med. Chem., 1987, 30, 574-580, J. B. Summers et al.

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