N-hydroxyamide derivatives and use thereof

Details N-hydroxyamide derivatives and use thereof N-hydroxyamide derivatives and use thereof

2011-08-16

2011-08-16

Jarrell, Noble (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S391000

Reexamination Certificate

active

07998964

ABSTRACT:
The present invention is related to N-hydroxyamide derivatives of Formula (I) and use thereof in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.

REFERENCES:
patent: 6908911 (2005-06-01), Hunter et al.
patent: WO 99/39704 (1999-08-01), None
patent: WO 01/10834 (2001-02-01), None
patent: WO 01/10834 (2001-02-01), None
patent: WO 01/10835 (2001-02-01), None
Clark, et al., Expert Opinion Ther. Targets, 7(1): 19-34 (2003).
Galis, et al., Circ. Res., 90: 251-262 (2002).
Leppert, et al.. Brain Res. Rev., 36: 249-257 (2001).
Makrakis, et al., J. of Maternity Fetal & Neonatal Medicine 14(3): 170-176 (2003).
Skiles, J.W. et al. “The Design, Structure, and Therapeutic Application of Matrix Metalloproteinase Inhibitors”Current Medicinal Chemistry, Mar. 2001, pp. 425-474, vol. 8, No. 4.
Wada, C.K. et al. “Phenoxyphenyl Sulfone N-Formylhydroxylamines (Retrohydroxamates) as Potent, Selective, Orally Bioavailable Matrix Metalloproteinase Inhibitors”Journal of Medicinal Chemistry, 2002, pp. 219-232, vol. 45.
“MMP-12 Inhibitors” Expert Opinion on Therapeutic Patents, 2004, pp. 1637-1640, vol. 14, No. 11, Ashley Publications.

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