N-hydroxy, N-methyl propanamides

Details N-hydroxy, N-methyl propanamides N-hydroxy, N-methyl propanamides

1991-09-26

1992-05-26

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Hydroxamic acids, chalcogen analogs or salts thereof

562622, C07C25908

Patent

active

051170540

ABSTRACT:
The invention provides a process for preparing 1,5-diaryl pyrazole anti-inflammatory agents. A 6-aryl-4,6-dioxohexanoic acid is treated with acetic anhydride or acetyl chloride to produce an enol lactone, which is added to methylhydroxylamine to generate the dione hydroxamic acid. This dione hydroxamic acid is then treated with 4-methoxyphenylhydrazine hydrochloride to yield the 1,5-diaryl pyrazole. Novel intermediate compounds in the synthetic pathway are also disclosed.

REFERENCES:
patent: 4218478 (1980-08-01), Omura et al.

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