N-homocysteine thiolactonyl retinamido cobalamin and methods of

Details N-homocysteine thiolactonyl retinamido cobalamin and methods of N-homocysteine thiolactonyl retinamido cobalamin and methods of

1988-07-14

1990-05-15

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 86, 514 52, 549 29, C07H 19167, C07D33320, A61K 31365, A61K 3138

Patent

active

049259318

ABSTRACT:
N-Homocysteine thiolactonyl retinamido cobalamin is useful for decreasing the induction of chemically-induced tumors in animals. It is also useful for inhibiting weight gain.

REFERENCES:
patent: 4255443 (1981-03-01), McCully
patent: 4364939 (1982-12-01), Aurissier et al.
patent: 4383994 (1983-05-01), McCully
patent: 4465775 (1984-08-01), Houts
patent: 4618685 (1986-10-01), McCully
F. G. Arsenyan et al., "Influence of Methylcobalamin on the Antineoplastic Activity of Methotrexate," Khimiko-Farmatsevticheskii Zhurnal, vol. 12, (1978), pp. 1299-1303 (translation).
P. Boerner et al., "Methionine-Sensitive Glycolysis in Transformed Cells," Proc. Natl. Acad. Sci. U.S.A., vol. 82, (1985), pp. 6750-5764.
R. Gaggi et al., "The Role of Homocysteine in the Pathogenesis of Arteriosclerosis," proceedings of the First Congress of the Hungarian Pharmacological Society (Budapest), vol. 2, (1973), pp. 287-297.
R. M. Hoffman, "Altered Methionine Metabolism, DNA Methylation and Oncogene Expression in Carcinogenesis," Biochimica et Biophysica Acta, vol. 738, (1984), pp. 49-87.
J. C. Linnell et al., "Altered Cobalamin Distribution in Rat Hepatomas and in the Livers of Rats Treated with Diethylnitrosamine," Cancer Research, vol. 37, (1977), pp. 2975-2978.
K. S. McCully et al., "Production of Arteriosclerosis by Homocysteinemia," Am. J. Pathology, vol. 61, (1970), pp. 1-11.
K. S. McCully et al., "Homocysteine Theory of Arteriosclerosis," Atherosclerosis, vol. 22, (1975), pp. 215-227.
K. S. McCully et al., "Homocysteine Thiolactone Metabolism in Malignant Cells," Cancer Research, vol. 36, (1976), pp. 3198-3202.
K. S. McCully et al., "Homocysteine Compounds Which Influence the Growth of a Malignant Neoplasm," Chemotherapy, S. Karger, Basel, vol. 23, (1977), pp. 44-49.
K. S. McCully et al., "Antineoplastic Activity of a Rhodium Trichloride Complex of Oxalyl Homocysteine Thiolactone," Cancer Investigation, vol. 5, (1987), pp. 25-30.
K. S. McCully et al., "Chemopreventive and Antineoplastic Activity of N-Homocysteine Thiolactonyl Retinamide," Carcinogenesis, vol. 8, (1987), pp. 1559-1562.
K. S. McCully et al., "Homocysteine Thiolactone, N-Homocysteine Thiolactonyl Retinamide, and Platelet Aggregation," Research Communications in Chemical Pathology and Pharmacology, vol. 56, (1987), pp. 349-360.
K. S. McCully et al., "Homocysteine Thiolactone in Arteriosclerosis and Cancer," Research Communications in Chemical Pathology and Pharmacology, vol. 59, (1988), pp. 107-119.

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