N-homocysteine thiolactonyl retinamide and use thereof as an ant

Details N-homocysteine thiolactonyl retinamide and use thereof as an ant N-homocysteine thiolactonyl retinamide and use thereof as an ant

1985-12-18

1986-10-21

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D33336, A61K 3138

Patent

active

046186859

ABSTRACT:
This invention is concerned with a new compound, useful to reduce tumors in laboratory animals, having the following structural formula: ##STR1## The compound is prepared by reacting the free base of homocysteine thiolactone with all trans retinoic acid in the presence of dicyclohexylcarbodiimide as a dehydrating agent as follows: ##STR2## The reaction is carried out in a suitable non-polar solvent. The compound may also be used to agglutinize human blood platelets.

REFERENCES:
patent: 4255443 (1981-03-01), McCully
patent: 4383994 (1983-05-01), McCully
Bollag, The Lancet, pp. 860-863, Apr. 16, 1983.
du Vigneaud, et al., Journal of Biological Chemistry, 126:217-231, 1938.
McCully and Ragsdale, The Am. J. of Pathology, 61(1):1-8, Oct. 1970.
Moon, et al., The Retinoids, vol. 2, pp. 327-371, Academic Press, 1984.
Spindel et al., Biochimica et Biophysica Acta, 343:687-691, 1974.
McCully et al., Atherosclerosis, 22:215-227, 1975.
McCully et al., Chemotherapy, 23:44-49, 1977.

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