Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-12-29
1996-09-17
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514255, 514256, 514269, 514275, 514352, 514361, 514362, 514363, 514364, 514366, 514367, 514370, 514372, 514373, 514375, 514377, 514379, 514380, 514383, 514386, 514392, 514404, A61K 3150, A61K 3144, A61K 3141
Patent
active
055568556
ABSTRACT:
A compound of the formula Het--NR--SO.sub.2 --Ph.sup.2 --A--Ph.sup.1 (COOH)(OH) and tautomic form, salts, solvates, C.sub.1-6 alkyl esters and pharmaceutical compositions of the compound. Ph.sup.1 and Ph.sup.2 are benzene rings with the proviso that carboxy and hydroxy are ortho to one another. Het includes an optionally substituted heterocyclic ring which includes conjugated double bonds and binds to nitrogen in NR. The compound is characterized in that A is a bridge which is stable against reduction because it is not azo, and in that R is hydrogen or lower alkyl.
The invention also includes the preparation of the compound and its use as a drug, particularly for treating autoimmune diseases.
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Agback Hubert
Ahrgren Leif
Berglindh Thomas
Haraldsson Martin
Olsson Lars-Inge
Covington Raymond
Ivy C. Warren
Pharmacia AB
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