N-heterocyclic platinum complexes

Details N-heterocyclic platinum complexes N-heterocyclic platinum complexes

1988-02-24

1989-04-18

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548950, 548955, A61K 31555, C07F 1500

Patent

active

048228923

ABSTRACT:
Novel platinum complexes represented by the formula: ##STR1## wherein A is alkylene having carbon atoms of from 1 to 3; R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and are hydrogen or alkyl having carbon atoms of from 1 to 4; X and Y are independently a halogen atom, or combined together to form ##STR2## and l, m and n are independently 0 or 1, and a process for preparing the same are disclosed.
These platinum complexes have high antitumor activity and low toxicity, and are easily soluble in water. Therefore, they are very useful as an antitumor agent.

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