N-heterocyclic inhibitors of TNF-α expression

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C544S197000, C544S198000, C544S208000, C544S209000, C544S213000, C544S217000, C544S218000

Reexamination Certificate

active

06906067

ABSTRACT:
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I:Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.

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