Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent
Reexamination Certificate
2005-03-08
2005-03-08
Raymond, Richard L. (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen in the nitrogen containing substituent
C544S060000, C544S122000, C544S295000, C544S298000, C544S320000, C544S324000, C544S331000
Reexamination Certificate
active
06864368
ABSTRACT:
N-Heterocyclic derivatives of the formula (I):are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
REFERENCES:
patent: 5244865 (1993-09-01), Seitz et al.
patent: 5426110 (1995-06-01), Gossett et al.
patent: 5489591 (1996-02-01), Kobayashi et al.
patent: 5663334 (1997-09-01), Sheldrake et al.
patent: 6172005 (2001-01-01), Selby
patent: 6432947 (2002-08-01), Arnaiz et al.
patent: 20020010190 (2002-01-01), Davey et al.
patent: 0 257 850 (1988-03-01), None
patent: 0 640 599 (1995-03-01), None
patent: WO9614842 (1996-05-01), None
patent: WO9614844 (1996-05-01), None
patent: WO9809960 (1998-03-01), None
Feldman et al., “The Surprising Life of Nitric Oxide”,Chemical and Engineering News(1993) 26-38.
Del Corona et al., “Synthesis and in vitro study of platelet antiaggregant activity of 2(4)-imidazol-1-yl-4(2)-cycloalkylaminopyrimidines”,Eur.J. Med. Chem. (1991). 26(7):729-733.
Fujisawa et al., “Inducible Nitric Oxide Synthase in a Human Glioblastoma Cell Line”,J. Neurochem.(1995) 64(1): 85-91.
Damiani et al., “Fluorometric Determination of Nitrite”Talanta(1986)33(8): 649-652.
Nathan, “Nitric oxide as a secretory product of mammalian cells”,FASEB Journal(1992) 6:3052:3064.
Lampe et al., “A Novel Rearrangement of 1-(2-Aminoaryl)imidazoles”,J. Heterocyclic Chem(1994) 31:287-291.
Arnaiz Damian O.
Baldwin John J.
Davey David D.
Devlin James J.
Dolle, III Roland Ellwood
Berlax Laboratories, Inc.
Hermenau Ronald S.
Miyamoto Neil G.
Pharmacopeia Drug Discovery Inc.
Raymond Richard L.
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