N-heterocyclic alcohol derivatives

Details N-heterocyclic alcohol derivatives N-heterocyclic alcohol derivatives

1988-04-07

1991-01-01

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530323, 530331, 530332, 530800, A61K 3743, C07K 508

Patent

active

049818430

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sub.1 is an N-heterocyclic group as defined herein and Y can be --NH--, --O-- or --CH.sub.2 --, are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agents.

REFERENCES:
patent: 4629724 (1986-12-01), Ryono et al.
patent: 4668769 (1987-05-01), Hoover
Powers et al., "Inhibition of Human Leukocyte Elastase, Porcine Pancreatic Elastase and Cathepsin G by Peptide Ketones", Proceedings from the 9th American Peptide Symposium, Jun. 23-28, 1985, Univ. of Toronto, Canada.

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