N-heterocyclic alcohol derivatives

Details N-heterocyclic alcohol derivatives N-heterocyclic alcohol derivatives

1988-04-29

1992-09-29

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544140, 544141, C07D41312

Patent

active

051515130

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sub.1 is an N-heterocyclic group as defined herein, are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agents.

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S. Rosenberg et al., "Novel Renin inhibitors Containing Analogues of Statine Retro-Inverted at the C-Termini: specificity at the P.sub.2 Histidine Site," J. Med. Chem., 30, 1224-1228 (1987).
Powers et al., "Inhibition of Human Leukocyte Elastase, Porcine Pancreatic Elastase and Cathepsin G by Peptide Ketones", Proccedings from the 9th American Peptide Symposium, Jun. 23-28, 1985; Univ. of Toronto, Canada, pp. 819-822.
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Burger, Medicinal Chemistry 2nd Ed (1960); Interscience Publishers Inc., New York, NY; pp. 565-571, 579-581, 600, & 601.

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