Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-04-12
1987-09-29
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514332, 514341, 514357, 514397, 514399, 514400, 544296, 544335, 544333, 546265, 546278, 546337, 548336, 548341, 548342, C07D21356, C07D23926, C07D40112, A61K 3144
Patent
active
046969306
ABSTRACT:
Compounds of the formula: ##STR1## wherein R.sub.1 is --alkylene'-13 NH.sub.2 or --alkylene'--A'; R.sub.2, R.sub.3 and R.sub.4 are independently hydrogen or methyl; A and A' are, independently, unsubstituted or lower alkyl or aryl substituted pyridinyl, imidazolyl, or pyrimidinyl; and when, an asymmetric carbon is present, enantiomers thereof, or racemic mixtures thereof; or pharmaceutically acceptable salts thereof, are described. These compounds are useful as antiarrhythmic agents.
REFERENCES:
patent: 3812093 (1974-05-01), Fisher et al.
patent: 4218477 (1980-08-01), Boyes et al.
patent: 4394513 (1983-07-01), Eicken et al.
patent: 4415587 (1983-11-01), Diamond et al.
Journal of Medicinal Chemistry, 1979, vol. 22, No. 10.
Mullin, Jr. John G.
Nakamura Keiji
Tilley Jefferson W.
Watanabe Hiroshi
Bjorkman Dale A.
Boxer Matthew
Hoffmann-La Roche Inc.
Jiles Henry R.
Leon Bernard S.
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