N-heteroaryl-N'-phenylurea derivatives, their production and use

Details N-heteroaryl-N'-phenylurea derivatives, their production and use N-heteroaryl-N'-phenylurea derivatives, their production and use

1998-06-19

2000-08-22

Lambkin, Deborah C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549 43, A61K 3138, C07D33374

Patent

active

RE0368326

ABSTRACT:
An N-heteroaryl-N'-phenylurea derivative represented by the general formula (I): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are as defined in the description of the specification which is useful as a prophylactic and therapeutic agent for hypercholesterolemia, atherosclerosis and diseases caused by them.

REFERENCES:
patent: 4113731 (1978-09-01), Winters et al.
patent: 4157399 (1979-06-01), Sauter
patent: 5492929 (1996-02-01), Natsugari et al.
Farmaco, Edizione Scientifica, vol. 34, 1979, Pavia It, pp. 507-517, G. Winters et al, "Synthesis and Biological Activities of Some Indolo [2,3, isoquinoline] Derivatives", p. 516, paragraph 2, Table II.
Chemical Abstract, vol. 90, 87163k (1978).
Chemical Abstract, vol. 91, 175235m (1979).
Farmaco Edizione Scientifica, vol. 34, 1979, Pavia It, pp. 507-517, G. Winters et al. `Synthesis and Biological Activities of Some Indolo[2,3-c]isoquinoline Derivatives` p. 516, paragraph 2, table II.

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