Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-06-20
2008-08-05
Anderson, Rebecca L (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S211150, C514S217080, C514S248000, C514S252060, C514S414000, C514S367000, C514S387000, C514S405000, C548S454000, C548S159000, C548S217000, C546S112000, C544S090000, C544S049000, C540S552000, C540S567000, C540S582000, C540S602000
Reexamination Certificate
active
07407950
ABSTRACT:
The invention concerns compounds of general formula (I), wherein n, X1, X2, X3, X4, Z1, Z2, Z3, Z4, Z5and W are as defined herein.Said compounds are ligands of the TRPV1vanilloid receptor, and are therefore, useful for treating diseases associated with TRPV1receptors, such as pain and inflammation.
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Szallasi, et al., “The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept”, Nature Reviews | Drug Discovery, vol. 6, pp. 357-372, May 2007.
Szallasi, et al., “TRPV1: a therapeutic target for novel analgesic drugs?”, Trends in Molecular Medicine, vol. 12 (11), pp. 545-554, Nov. 2006.
Menendez, et al. “Analgesic effects of capsazepine and resiniferatoxin on bone cancer pain in mice”, Neuroscience Letters, vol. 393(1), pp. 70-73, (Jan. 2006).
Nagy, et al. “The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology”, European Journal of Pharmacology, vol. 500(1-3), pp. 351-369, (Oct. 2004).
Dubois Laurent
Evanno Yannick
Malanda André
Anderson Rebecca L
Barker Michael P
Gupta Balaram
Sanofi-Aventis
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