Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2006-01-25
2010-12-07
O'Sullivan, Peter G. (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C562S104000, C562S105000
Reexamination Certificate
active
07846971
ABSTRACT:
The present invention relates to active bactericidal, antibacterial, anti-infective, antimicrobial, sporicidal, disinfectant, antifungal and antiviral compounds and compositions and to new uses of these compositions in therapy. This specification also describes methods of use for the new compounds and compositions. The specification further describes methods for preparing these compounds. FIG.1: A dual chamber apparatus for the preparation of NNDCT on site.
REFERENCES:
patent: 3950536 (1976-04-01), Barer et al.
patent: 3966796 (1976-06-01), Kaminski et al.
patent: 3998945 (1976-12-01), Vit et al.
patent: 4015008 (1977-03-01), Barer et al.
patent: 4045578 (1977-08-01), Kaminski et al.
patent: 4386103 (1983-05-01), Pogany et al.
patent: 5096700 (1992-03-01), Seibel et al.
patent: 5985239 (1999-11-01), Hussain et al.
patent: 6451761 (2002-09-01), van Gelder
patent: 7129259 (2006-10-01), Chen et al.
patent: 2004/0022871 (2004-02-01), Mainnemare
patent: 2005/0065115 (2005-03-01), Bassiri et al.
patent: 4041703 (1992-07-01), None
patent: 4041703 (1992-07-01), None
patent: 4041703 (1992-07-01), None
patent: 198 16 102 (1998-09-01), None
patent: 197 12 565 (1998-10-01), None
patent: 19712565 (1998-10-01), None
patent: 19816102 (1999-09-01), None
patent: 07206609 (1995-08-01), None
patent: WO 02/22118 (2002-03-01), None
patent: 02058692 (2002-08-01), None
patent: WO 02/058692 (2002-08-01), None
patent: WO 2005/020896 (2005-03-01), None
patent: WO 2008/083347 (2008-07-01), None
Egawa, et al.; “Reactions of N,N-dichloroalkylamines with solid base as studied by FTIR combined with DFT calculations” J. Mol. Struct. (2001), 560(1-3):337-344.
Advances in Pharmaceutical Sciences vol. 7. (Eds., 1995).
Bozeman P. et al., “Oxidation of Bromide by the Human Leukocyte Enzymes Myeloperoxidase and Eosinophil Peroxidase”,J. Bio. Chem., 7, pp. 2906-2913, 1995.
Braghiroli, D. et al., “New Methods for the Preparation of 2-Amino-2-methylpropanesulfonic Acid”,Tetrahedron Letters, vol. 37, pp. 7319-7322, 1996.
Brown, H.C.; “Organic Synthesis via Boranes”, Wiley-Interscience: New York, 1975.
Chinake, et al., “Oxyhalogen-sulfur Chemistry: Kinetics and Mechanism of the Oxidation of a Bunte Salt 2-Aminoethanethiolsulfuric Acid by Chlorite”,Phys. Chem. Chem. Phys; vol. 3: pp. 4957-4964, 2001.
Davies, et al.,Neurosci. Lett. 21: pp. 77-81, 1981.
E. A. Boyd, M. et al., “A Versatile Route to Substituted Phosphinic Acids”, Tetrahedron Lett., 1990, 31, 20, 2933-2936.
Evans, R.H. et al., “The Effects of a Series of ω-Phosphonic α-Carboxylic amino Acids on Electrically Evoked and Excitant Amino Acids-Induced Responses in Isolated Spinal Cord Preparations”, Br. J. Pharmac., vol. 75, pp. 65-75, 1982.
G. M. Kosolapoff, The Synthesis of Phosphonic and Phosphinic Acids, Organic Reactions, vol. 6 (1951).
Gelder, N.M., et al., Synthesis and characterization of N,N-dichlorinated amino acids: Taurine, Homotaurine, GABA and L-Leucine;J. Neurochemical Research; 26: pp. 575-578 2001.
J Marcinkiewicz et al.,J of Inflammatory Research49, pp. 280-289 2000.
J. M. Antelo; F. Arce, J. Crugeiras, M. Parajó, “General acid-base catalysis in the reversible disproportionation reaction ofN-chlorotaurine”,J. Chem. Soc. Perkin Trans. 2, 2000, 2109-2114.
J. Phys. Chem. A. 1998; 102: pp. 9838-9846.
Kamatani, A., et al.,J. Org. Chem. 1999, 64, pp. 8743-8744.
Lapenna D., et al.,Gen. Pharmacol. Oct. 1996; 27(7): 1145-1147.
Mainnemare A, et al., Hypochlorous acid and taurine-N-monochloramine in periodontal disease;J Dent Res. 83 (11): pp. 823-831 (Nov. 2004).
Medical Plastics and Biomaterials Magazine, Mar. 1998, p. 30.
Merck Index, Thirteenth Edition, 2001, Entries 2084 and 2085 on p. 356.
Miyaura, N. and Suzuki, A. Chem. Rev. 1995, 95, pp. 2457-2483.
Nagl, M.Arch. Pharm. Med. Chem. 2002, 9, pp. 411-421.
Prof. R. Noyori Nobel Lecture “Asymmetric Catalysis: Science and Opportunities” dated Dec. 8, 2001 (www.nobel.se/chemistry/ laureates/2001
oyori-lecture.pdf).
R. P. Singh and K. M. Shreeve,Chem. Commun., 2001, pp. 1196-1197.
Ray Williams, “Periodontal Disease”, New England Journal of Medicine 322: pp. 373-382, 1990.
Remington's Pharmaceutical Sciences, 17th ed., Mack Publishing Company, Easton, Pa., 1985, p. 1418.
Ryglowski, A et al, “The Facile Synthesis of Dialkyl 1-AminoalkylphosphonatesSynth. Commun.”, pp. 2725-2731 (1994).
S. Kjelleberg, et al., “Is there a role for quorum signals in bacterial biofilms?” (PubMed—indexed for Medline).
Santaballa, J.A. et al., “Aqueous Chemistry of N-halo-compounds”,Chemical Society Reviews, vol. 27, p. 453-460, 1998.
Scudiero DA, Shoemaker Rah, Paul KD, Monks A, Tierney S, Nofziger TH, Currens MJ, Seniff D, Boyd MR. Cancer Res.; Sep. 1;48 (17): pp. 4827-48733 1988.
Suzuki, A.J. Organometallic Chem.; 576, pp. 147-168 1999.
Suzuki, A.Pure Appl. Chem.; 66, p. 213-222 1994.
Tetrahedron: Asymmetry; 8 (13), pp. 2189-2192 1997.
The Chemical Formulary, H. Bennett Ed., Chemical Publishing Company, vol. XXXIV, pp. 163-171 1998.
Thomas EL.; Grisham MB, Jefferson MM.Meth. Enzymol; 132, pp. 585-593 1986.
V. V. Rozhkov, K. N. Makarov, R. G. Kostyanovsky, “N-Fluorination of aziridinecarboxylates via fluorolysis of their N-aminomethyl derivatives”,Mendeleev Commun., 1998, 66-67.
Webb, K. S. and Levy D.Tetrahedron Lett.; 36, p. 5117 1995.
Weiss S.J., Klein R., Slivka A., Wei M.J. Clin. Invest.; Sep.; 70(3): pp. 598-607 1982.
Yang, W.; Gao, S.; Wang, B. “Boronic Acid Compounds as Potential Pharmaceutical Agents”Med. Res. Rev.; 23, pp. 346-368 2003.
Yuan, C. et al, New Strategy for the Synthesis of Functionalized Phosphonic Acids, Heteroatom Chem.; 8 (2) pp. 103-122 1997.
Yuan, C., et al., New strategy for the Synthesis of Functionalized Phosphonic Acids, Pure Appl. Chem.; 68(4), pp. 907-912 1996.
Zboinska et al.,FEMSMicrobiol.Lett. 108, pp. 225-230 1993.
Zboinska et al., FEMS Microbiol. Lett., 70, pp. 23-28 1990.
Abrantes, et al.; “Determination of Extractable Biocides in Paper Food Packaging Materials Using Micellar Electrokinetic Chromatography”; J. Microcolumn Separations (1998), 10(5):387-391.
Kaminski, et al.; “N-Halo Derivatives IV: Synthesis of Low Chlorine Potential Soft N-Chloramine Systems”; Journal of Pharmaceutical Sciences (1976), 65(12):1733-1737.
Kaminski, et al.; “N-Halo Derivatives V: Comparative Antimicrobial Activity of Soft N-Chloramine Systems”; Journal of Pharmaceutical Sciences (1976), 65(12):1737-1742.
Kosugi, et al.; “N-Halo Derivatives VI: Microbiological and Chemical Evaluations of 3-Chloro-2-oxazolidinones”; Journal of Pharmaceutical Sciences (1976), 65(12):1743-1746.
Nagl, et al.; “Activity of N-chlorotaurine against herpes simplex and adenoviruses”; Antiviral Research (1998), 38:25-30.
Nagl, et al.; “Rapid Killing ofMycobacterium terraeby N-Chlorotaurine in the Presence of Ammonium is Caused by the Reaction Product Monochloroamine”; J. Pharm. Pharmacol. (1998), 50:1317-1320.
Nagl, et al.; “Tolerance of N-Chiorotaurine, a new Antimicrobial Agent, in infectious Conjunctivitis—A Phase II Pilot Study”; Ophthalmologia (2000), 214:111-114.
Nagl, et al.; “Enhanced Fungicidal Activity of N-Chlorotaurine in Nasal Secretion”; J. Antimicrobial Chemotherapy (2001), 47:871-874.
Nagl, et al.; “Impact of N-Chlorotaurine on Viability and Production of Secreted Aspartyl Proteinases ofCandida spp.”; Antimicrobial Agents and Chemotherapy (2002), 46(6):1996-1999.
Roberts, et al.; “Chemistry of N-Halo Compounds. 33. Pyrolytic Eliminations from N,N-Dichloro Derivatives of Primary, Secondary, and Tertiary Alkyl Primary Amines”; J. Org. Chem. (1981), 46(21):4111-15.
Schmitz, et al.; “Conversion of 4-aminoheptane to pyrrolizidine”; Chemische Berichte (1960), 93:754-756.
White, et al.; “Relative Migratory Aptitudes in the Rearrang
Bassiri Mansour
Khosrovi Behzad
Najafi Ramin
Wang Lu
Hamilton Desanctis & Cha LLP
Novabay Pharmaceuticals, Inc.
O'Sullivan Peter G.
LandOfFree
N-halogenated amino acids, N,N-dihalogenated amino acids and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with N-halogenated amino acids, N,N-dihalogenated amino acids and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-halogenated amino acids, N,N-dihalogenated amino acids and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4227123