Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-08-23
2011-08-23
Wilson, James O. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S322000, C544S336000, C546S304000, C548S136000, C548S202000, C548S214000, C548S235000, C548S247000, C548S375100
Reexamination Certificate
active
08003654
ABSTRACT:
The invention relates to novel sulfonamide compounds of the formula (I)and their use as orexin receptor antagonists.
REFERENCES:
patent: 7279578 (2007-10-01), Aissaoui et al.
patent: 7396958 (2008-07-01), Courtemanche et al.
patent: 7435815 (2008-10-01), Aissaoui et al.
patent: WO00/50391 (2000-08-01), None
patent: WO02/32864 (2002-04-01), None
patent: WO2004/033418 (2004-04-01), None
patent: WO2004/058702 (2004-07-01), None
patent: WO2005/118548 (2005-12-01), None
patent: WO2006/024779 (2006-03-01), None
Ashimori et al., Novel 1,4-Dihydropyridine Calcium Antagonists. I. Synthesis and Hypotensive Activity of 4-(Substituted Pyridyl)-1,4-dihydropyridine Derivatives, Chem. Pharm. Bull., vol. 38, No. 9, 2446-2458 (1990).
Buttimore et al., Isothiazoles, Part II1Isothiazolealdehydes and Isothiazolyl Ketones, J. Amer. Chem. Soc., 2032-2039 (1963).
Buttimore et al., Isothiazoles, Part VIII1Reactions of 3-Bromomethylisothiazoles, J. Amer. Chem. Soc., 7274-7276 (1965).
Calderwood et al., Selective Tolyl Carbon Alkylation Mediated by Imidazoline-Directed Lithiation, Synth. Commun., vol. 34, No. 19, 3455-3464 (2004).
Chemelli et al., Narcolepsy inorexinKnockout Mice: Molecular Genetics of Sleep Regulation, Cell, vol. 98, 437-451 (Aug. 20, 1999).
Comins et al., Lithiation of Methoxypyridines Directed by α-Amino Alkoxides, J. Org. Chem., 55, 69-73 (1990).
Deshong et al., A General Method for the Synthesis of Tetramic Acid Derivatives, J. Org. Chem., 53, 1356-1364 (1988).
Eiermann et al., [2.2](2,6)- and [2,2](2,5)Pyrazinophanes: Synthesis and Molecular Structure, Chem. Ber., 123, 523-533 (1990).
Gibson (Editor), Pharmaceutical Preformulation and Formulation, IHS Health Group, Englewood CO, USA (2001).
Gould, Salt Selection for Bacis Drugs, International Journal of Pharmaceutics, 33, 201-217 (1986).
Hamilton et al., The Preparation of Aromatic Arsonic and Arsinic Acids by the Bart, Bechamp, and Rosenmund Reactions, Org. React., 2, 428 (1944).
Juanes et al., Synthesis of Macrobicyclic Ligands containing Pyrazole Subunits: theN,N′-Bibyrazolyl Cryptand, Chem. Soc. Chem. Commun., 24, 1765-1766 (1985).
Kemnitzer et al., Discovery of 4-Aryl-4H-chromenes as a New Series of Apoptosis Inducers Using a Cell- and Caspase-based High Throughput Screening Assay. 1. Structure-Activity Relationships of the 4-Aryl Group, J. Med. Chem., 47, 6299-6310 (2004).
Khanna et al., Selective Cyclooxygenase-2 Inhibitors: Heteroaryl Modified 1,2-Diarylimidazoles Are Potent, Orally Active Antiinflammatory Agents, J. Med. Chem. 43, 3168-3185 (2000).
Li et al., Synthesis and Biological Evaluation ofN-Heterocylic Indolyl Glyoxylamides as Orally Active Anticancer Agents, J. Med. Chem., 46, 1706-1715 (2003).
Ma et al., Novel Chelating Agents for Potential Clinical Applications of Copper, Nuclear Medicine and Biology, 29, 91-105 (2002).
Newkome et al., α-Methyl Functionalization of Electron-Poor Hetercycles1: Free Radical Chlorination, Synthesis, 676-679 (1984).
Pattenden et al., Total Synthesis of (+)-phorboxazole A, a Potent Cytostatic Agent from the SpongePhrobassp., Org. & Biomolecular Chem., 1, 23, 4173-4208 (2003).
Russell et al., Discovery of Functionally Selective 7,8,9,10-Tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalizines as GABAAReceptor Agonists at the α3Subunit, J. Med. Chem., 48, 1367-1383 (2005).
Sakurai et al., Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptor that Regulate Feeding Behavior, Cell, vol. 92, 573-585 (Feb. 20, 1998).
Aissaoui Hamed
Boss Christoph
Gude Markus
Koberstein Ralf
Sifferlen Thierry
Actelion Pharmaceuticals Ltd.
Hoxie & Associates LLC
Willis Douglas M
Wilson James O.
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