N-formyl hydroxylamines

Details N-formyl hydroxylamines N-formyl hydroxylamines

2006-05-22

2009-11-10

Berch, Mark L (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S224000, C544S329000, C544S408000, C544S409000, C546S279100, C549S419000, C548S230000, C548S532000

Reexamination Certificate

active

07615635

ABSTRACT:
Novel N-formyl hydroxylamine compounds and their derivatives are disclosed. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and use of the compounds are also disclosed.

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Fritsche, Thomas R. et al., “Comparative Antimicrobial Characterization of LBM415 (NVP PDF-713), a New Peptide Deformylase Inhibitor of Clinical Importance,”Antimicrobial Agents and Chemotherapy, vol. 49(4):1468-1476 (2005).

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