N-formyl hydroxylamine derivatives as inhibitors of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S300100, C548S302700, C548S309700, C548S310100, C514S393000

Reexamination Certificate

active

10432252

ABSTRACT:
Compounds of formula (I) are antibacterial or antiprotozoal agents for treatment of infections in humans and non-human mammals, wherein: Z represents a radical of formula —N(OH)CH(═O) or formula C(═O)NH(OH); R1represents hydrogen, methyl or trifluromethyl, or except when Z is a radical of formula —N(OH)(═O), a hydroxy, halo or amino group; R2represents a group R10—(X)n-(ALK)m— wherein R10, ALK, X, m and n are as defined in the specification; R3represents hydrogen, (C1–C6) alkyl or phenyl(C1–C6)alkyl-; and R5and R6are as defined in the specification.

REFERENCES:
patent: 5665753 (1997-09-01), Frazee et al.
patent: 5703092 (1997-12-01), Xue et al.
patent: 5733882 (1998-03-01), Carr et al.
patent: WO 95 23790 (1995-09-01), None
patent: WO 96 33176 (1996-10-01), None
patent: WO 99 39704 (1999-08-01), None
patent: WO 99 59568 (1999-11-01), None
patent: WO 00 61134 (2000-10-01), None
Chen et al.: “Design, synthesis, activity, and structure of a novel class of matrix metalloproteinase inhibitors containing a heterocyclic P2'-P3' amide bond isostere”; Bioorganic & Medicinal Chemistry Letters; vol. 6, No. 13, Jul. 9, 1996; pp. 1601-1606; XP004175762.

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