N-formyl and N-desmethyl leurosine derivatives

Details N-formyl and N-desmethyl leurosine derivatives N-formyl and N-desmethyl leurosine derivatives

1973-12-05

1980-02-19

Wheeler, David

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D51904

Patent

active

041894324

ABSTRACT:
Leurosine derivatives of the formula (I), ##STR1## wherein R is hydrogen or formyl, or pharmaceutically acceptable acid addition salts thereof were prepared by oxidizing leurosine or an acid addition salt thereof, optionally formylating the thus-obtained product and then separating, and, if desired, converting any of the free bases into its acid addition salt. The new compounds of the invention possess strong cytostatic activity, and can be used in the human therapy with great advantage.

REFERENCES:
patent: 3392173 (1968-07-01), Hargrove
patent: 4065457 (1977-12-01), Buckle et al.
"Cancer Chemotherapy Reports," vol. 1, pp. 9-18 (1959).
DeGroot et al., Journ. Org. Chem., vol. 31, pp. 3954-3958.

Affiliated with

Also associated with

Rating

N-formyl and N-desmethyl leurosine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N-formyl and N-desmethyl leurosine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-formyl and N-desmethyl leurosine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-652952