Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1976-10-01
1977-12-13
Demers, Arthur P.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260465R, 260562R, 2605709, 424330, C07C10337
Patent
active
040628914
ABSTRACT:
The new 4-aminomethyldibenzobicyclo[ 5.1.0] octane compounds of the present invention are prepared from the corresponding 4-halo compounds by reaction with a metal cyanide to produce the corresponding 4-cyano compound, which is reduced with an alkali metal aluminum hydride to produce the desired 4-aminomethyl compound. These new aminomethyldibenzobicyclo[ 5.1.0] octane compounds are converted to the corresponding secondary and tertiary amino derivatives.
These new compounds are useful as antiarrhythmic agents and can be used to overcome cardiac irregularities.
REFERENCES:
patent: 3423461 (1969-01-01), Kaiser et al.
patent: 3574199 (1971-04-01), Coyne et al.
Arther Thomas E.
Demers Arthur P.
Merck & Co. , Inc.
Szura Daniel T.
Westlake, Jr. Harry E.
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