N-(Dichloroacetyl) diamine compounds and process of preparing sa

Details N-(Dichloroacetyl) diamine compounds and process of preparing sa N-(Dichloroacetyl) diamine compounds and process of preparing sa

1977-09-09

1978-09-12

Curtis, Allen B.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260561HL, C07C10206, C07C10222

Patent

active

041137744

ABSTRACT:
N-(Dichloroacetyl)-N'-(mono- or di-chlorobenzoyl)-1,8-octanediamines (I), acetaldehyde dehydrogenase inhibitors, indicating their usefulness as aids in treating alcoholism, are prepared by reacting a mono-acid-addition salt of 1,8-ocetanediamine with one molar equivalent quantity of a lower-alkyl dichloroacetate to produce N-(dichloroacetyl)-1,8-octanediamine and then reacting it with a mono- or di-chlorobenzoylating agent to produce I. Also shown is the process of reacting a mono-acid-addition salt of 1,6-hexanediamine with one molar equivalent quantity of a lower-alkyl dichloroacetate to produce N-(dichloroacetyl)-1,6-hexanediamine.

REFERENCES:
patent: 2764603 (1956-09-01), Ahlbrecht
patent: 3677739 (1972-07-01), Horrom et al.
Coulston, F. et al., "The Biologic Actions of a New Series of Bis(dichloroacetyl) Diamines, Toxicology and Applied Pharmacy, 2, 715-731 (1960).

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