N-dealkylation of N-alkyl-14-hydroxymorphinans and derivatives t

Details N-dealkylation of N-alkyl-14-hydroxymorphinans and derivatives t N-dealkylation of N-alkyl-14-hydroxymorphinans and derivatives t

1976-12-20

1979-02-27

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 74, 546 46, C07D48908

Patent

active

041418972

ABSTRACT:
There is provided a novel, high yield, method of dealkylating N-alkylated 14-hydroxymorphinans and derivatives thereof including, inter alia, oxymorphone and oycodone. There are thus provided, inter alia, more efficient routes for the formation of naloxone, naltrexone, and nalbuphine. In the principal step of the process, the dealkylation using certain oxycarbonyl halides (or haloformates) is carried out on the N-alkyl-14-acyloxy-morphinan which it is desired to dealkylate.

REFERENCES:
patent: 3230224 (1966-01-01), Sawa et al.
patent: 3254088 (1966-05-01), Lewenstein et al.
patent: 3285922 (1966-11-01), Gates, Jr.
patent: 3320262 (1967-05-01), Lewwnstein et al.
patent: 3828050 (1974-08-01), Buckett et al.
patent: 3872127 (1975-03-01), Merz et al.
patent: 3905981 (1975-09-01), Olofson et al.

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