N-deacetylthiocolchicine derivatives, their use and...

Details N-deacetylthiocolchicine derivatives, their use and... N-deacetylthiocolchicine derivatives, their use and...

2008-06-19

2009-08-25

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S204000

Reexamination Certificate

active

07579364

ABSTRACT:
Disclosed is a series of N-deacetylthiocolchicine derivatives of formula Iin which:the linker is a bivalent straight or branched C1-C8alkyl residue, C3-C8cycloalkyl, a phenylene or heterocyclic C4-C6ring;the G1and G2junctions, which can be the same or different, are —CO—, —CONH—, —CR2— groups in which R2is hydrogen or a straight C1-C4alkyl residue,or the G1-linker-G2group is the —CO— group.The compounds of formula I have antiproliferative, antiinflammatory, antiarthritic and antiviral activity.

REFERENCES:
patent: 3090729 (1963-05-01), Bellet et al.
patent: 2004/0204370 (2004-10-01), Yang
patent: 01/68597 (2001-09-01), None
patent: WO 01/68597 (2001-09-01), None

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